Process for the continuous preparation of sterile, depyrogenated

Details Process for the continuous preparation of sterile, depyrogenated Process for the continuous preparation of sterile, depyrogenated

1985-04-24

1987-03-10

Castel, Benoit

Liquid purification or separation

Processes

Chemical treatment

210760, 210764, 210900, 422 28, C02F 178, C02F 172

Patent

active

046489789

ABSTRACT:
A process for sterilizing and depyrogenating a pretreated solution, such as water, by adding an oxidant selected from the group consisting of hydrogen peroxide and ozone and heating the solution and the oxidant to a temperature sufficient to sterilize and depyrogenate the solution for a period of time, preferably less than 5 minutes. The oxidant is thereafter removed and the sterilized, depyrogenated solution is cooled for dispensing.

REFERENCES:
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patent: 3549528 (1970-12-01), Armstrong
patent: 3870033 (1975-03-01), Faylor et al.
patent: 4070289 (1978-01-01), Akcasu
patent: 4548716 (1985-10-01), Boeve
Dr. Carl Nebel, "Ozone in High Purity Water Systems", Sixth Ozone World Congress Proceedings, International Ozone Association, May 23-26, 1983, Abstract.
Nebel, C. & Nebel, T., "Ozone, the Process Water Sterilant", Pharm. Manuf., Apr., 1984.
Arthur Cherkin, Destruction of Bacterial Endotoxin Pyrogenicity by Hydrogen Peroxide, Immunochemistry, 1975, vol. 12, pp. 625-627.
E. Menczel, A Note on the Depyrogenization of Infusion Solutions by Hydrogen Peroxide.
Abraham Taub and Fanchon Hart, Detoxification of Pyrogens by Hydrogen Peroxide in Some U.S.P. Injections, Journal of the American Pharmaceutical Association, Scientific Edition.

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