Process for the chlorination of .alpha.-aminoacids

Details Process for the chlorination of .alpha.-aminoacids Process for the chlorination of .alpha.-aminoacids

1979-04-11

1981-06-09

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C 5160

Patent

active

042724546

ABSTRACT:
A process for the chlorination of the carboxylic group of .alpha.-aminoacids is described whereby an aminoacid (e.g. p-hydroxy-phenyl-glycine) is suspended in an anhydrous solvent such as dioxane and treated with a chlorinating agent of the formula: ##STR1## in the presence of HCl in excess. The preferred chlorinating agent is chloromethylene-dimethylammonium chloride.

REFERENCES:
patent: 3869485 (1975-03-01), DeLong
patent: 3925418 (1975-12-01), Williams et al.
Hepburn, Derek R. et al., Chemistry and Industry (Aug. 1974) pp. 664-665.
Viehe, H. G. et al., Angew. Chem. internat. Ed., vol. 12 (1973), pp. 806-818.
Fieser & Fieser, Reagents for Organic Synthesis, vol. I (1967), pp. 286-287.
Zaoral, M. et al., Tetrahedron Letters, No. 14 (1960), pp. 9-12.

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