Process for the bioconversion of fumarate to L-malate

Details Process for the bioconversion of fumarate to L-malate Process for the bioconversion of fumarate to L-malate

1984-09-24

1988-03-29

Weimar, Elizabeth

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435911, 435914, 435920, 435929, 435932, 435933, C12P 746, C12R 1645, C12R 1665, C12R 171

Patent

active

047343680

ABSTRACT:
L-malic acid is produced in a concentration of 170 to 400 g per liter and high yield by biotechnical conversion of fumaric acid neutralized with ammonium hydroxide in nutrient-free solution or suspension. Pure L-malic acid can be obtained economically therefrom with high efficiency in a quality suitable for food and pharmaceutical use. The fermentation can be carried out in simple vessels under non-sterile conditions. The conversion rate of the fumarate and the attainable concentration of L-malate are promoted by the ammonium ions.

REFERENCES:
patent: 2972566 (1961-02-01), Kitahara
patent: 3063910 (1962-11-01), Abe et al.
patent: 3922195 (1975-11-01), Chibata et al.
patent: 3980520 (1976-09-01), Degen et al.
Sahni, V. P., "Some Effects of Organic Acid Supplementation on Utilization of Ammonium Compounds by Three Pathogenic Fungi", Mycopathologia et Mycologia applicata, vol. 43, pp. 4-48 (1971).
Kobayashi, G. S., "Fungi", Chap. 43, pp. 969-970 Microbiology (2nd ed.), Davis, et al. (Harper & Row, publ.) 1973.
Maruyama, et al. "Localization of Enzymes in the Mycelium and Microconidia of Fusarium oxysporum", J. Bact. 84: 307-312 (1962).
Davis, et al. "Organelle Isolation and Partial Characterization from Giant Cells of Aspergillus niger", FEMS Lett., 1 (1977), pp. 51-54.
Jong, et al. ATCC Catalogue of Fungi/Yeasts (16th ed., 1984), pp. 26, 158, 197, and 331.
Moat, A. G., Microbial Physiology (Wiley-Interscience publ.) 1979, p. 158.
S. Takao and K. Hotta, "Conversion of Fumaric Acid Fermentation to L-Malic Acid Fermentation by the Association of Rhizopus arrhizus and Proteus vulgaris", J. Ferment. Tech., vol. 54, 1976, pp. 197-199.
S. Takao, M. Tanida, and H. Kuwabara, "L-Malic Acid Production from Non-sugar Carbon Sources by Paecilomyces varioti, J. Ferment. Tech., vol. 55, No. 2, 1977, pp. 196-199.
T. Furukawa, T. Nakahara and K. Yamada, "Studies on the Utilization of Hydrocarbons by Microorganisms, Part XX, Conversion of Fumaric Acid to L-Malic Acid by the Association of Two Kinds of Yeast", Agr. Biol. Chem., vol. 34, No. 12, 1970, pp. 1833-1838.

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