Process for the asymmetric synthesis of chiral .alpha.-hydroxy-2

Details Process for the asymmetric synthesis of chiral .alpha.-hydroxy-2 Process for the asymmetric synthesis of chiral .alpha.-hydroxy-2

1986-10-31

1988-02-23

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 9900

Patent

active

047271833

ABSTRACT:
Disclosed herein is a process for producing an asymmetric indoline-2-carboxylic acid of the structural Formula: ##STR1## wherein X is hydrogen, bromine, chlorine, C.sub.1-4 alkyl or C.sub.1-4 alkoxy, which comprises:

REFERENCES:
patent: 4060626 (1977-11-01), Hrstka et al.
patent: 4614806 (1986-09-01), Buzby et al.
Houlihan, ed., The Chemistry of Heterocyclic Compounds, vol. 25, part 1, pp. 396-399 (Wiley Interscience, New York 1972).
Hudson, C. B. and Robertson, A. V., Australian Journal of Chemistry, 20, 1935-41 (1967).
Stanton et al., Journal of Medicinal Chemistry, 26, 1267-77, 68, (1983).
Corey et al., Journal of the American Chemical Society, 2476-2488, at 2480, (1970).
Vincent et al., Tetrahedron Letters, vol. 23, No. 16, 1677-80 at 1678, (Apr./May 1982).
Hepburn et al., Chem. Abstracts, 82: 3698n (1975).

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