Process for the analytical determination of acetylcyanamide in u

Details Process for the analytical determination of acetylcyanamide in u Process for the analytical determination of acetylcyanamide in u

1992-01-21

1993-03-09

Housel, James C.

Chemistry: analytical and immunological testing

Nitrogen containing

436109, 436 20, G01N 3300

Patent

active

051926903

ABSTRACT:
The present invention is directed to a process for the analytical determination of acetylcyanamide in urine. It involves (a) the separating of acetylcyanamide at from a urine matrix and/or an extract which is obtained from a urine matrix by ion exchange chromatography or reverse phase high performance liquid chromatography (HPLC), and (b) detecting the acetylcyanamide at a wavelength of 220 nm. The matrix or the extract of it is cleaned by treatment with activated carbon at pH 7 to 13, and the acetylcyanamide may be extracted from the cleaned matrix or its extract at pH 0.5 to 3.5, e.g. by liquid-liquid extraction of the acetylcyanamide. This is carried out by means of water-insoluble, organic solvent such as ethyl acetate or diethyl ether.

REFERENCES:
patent: 4692415 (1987-09-01), Rust
Shirota et al. "N-Acetylcyanamide, the Major Urinary Metabolite of Cyanamide in Rat, Rabbit, Dog and Man" CA101(3):16971g.

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