Process for the .alpha.-chlorination of phenylacetonitriles

Details Process for the .alpha.-chlorination of phenylacetonitriles Process for the .alpha.-chlorination of phenylacetonitriles

1992-06-05

1993-12-28

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

C07C25330, C07C25535

Patent

active

052741656

ABSTRACT:
Process for the .alpha.-chlorination of phenylacetonitriles, for example benzyl cyanide, in which the phenylacetonitrile is contacted with a suitable chlorinating agent, sulphuryl chloride or chlorine gas, while an amount of strong acid, preferably HCl, is also present in the reaction mixture. The induction time and the reaction rate are dependent on, among other factors, the concentration of the acid. Preferably, the reaction is carried out under pressure. The reaction is well controllable.

REFERENCES:
patent: 2302228 (1942-11-01), Kharasch et al.
patent: 3331865 (1967-07-01), Weil et al.
patent: 3828088 (1974-08-01), Shuman
patent: 3880927 (1975-04-01), Molloy
Ohoka et al., "Reaction of Nitriles With Thionyl Chloride . . . ", Journal of Organic Chemistry, vol. 40, No. 24, 1975, pp. 3540-3544.
Hantzsch, "Uber Die Vermeintlichen . . . ", Berichte der Deutschen Chemischen Gesellschaft, vol. 64, 1931, pp. 667-678.

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