Process for testing gene-disease associations

Details Process for testing gene-disease associations Process for testing gene-disease associations

1993-10-19

1995-11-07

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 4, 435 911, 435 912, 536 231, 536 243, 536 2431, C12Q 100, C12Q 168

Patent

active

054647428

ABSTRACT:
The present invention describes a process to test the association of an allele and a disease, especially a non-Mendelian disease. The process involves a comparison of the proportion of test individuals who have the disease and carry the allele from a set of families in which the allele is present and the proportion of test individuals expected to carry the allele if there is no association between the gene and the disease.

REFERENCES:
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Berg et al. Nature. 313:369 (1985).
Lander et al. P.N.A.S. 83:7353-57 (1986).
Berg et al. Diabotologia 3:30-34 (1967).
Woolf. B. Ann. Hum. Genet. 19:251-53 (1955).
Schlesselman J. in Case Control Studies. CHAP 6 Sample Size Oxford Univ. Press. N.Y., (1982).
Fleiss J. in. Statistical Methods for Rates and Proportions. Chap 2. Assessing significance in a 4.times.4 Table John Wiley N.Y. (1984).
Gillis P. Interdi Sci. Reviews. 4(4) 307 (1979).

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