Process for synthesizing oil and surfactant-free hyaluronic...

Details Process for synthesizing oil and surfactant-free hyaluronic... Process for synthesizing oil and surfactant-free hyaluronic...

2004-11-03

2009-10-13

Jiang, Shaojia Anna (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S053000

Reexamination Certificate

active

07601704

ABSTRACT:
A method for synthesizing uniformly sized hyaluronic acid (“HA”) particles that are substantially free from oil and surfactant contaminants. The method comprises crosslinking HA chains with 1-ethyl-3-(3-dimethlyaminopropyl) carbodiimide hydrochloride (“EDAC”) and adipic acid dihydrazide in a water/acetone mixture.

REFERENCES:
patent: 5616568 (1997-04-01), Pouyani et al.
patent: 6221397 (2001-04-01), Russell-Jones et al.
Ikada, Y. et al, Journal of Polymer Science: Part A: Polymer Chemistry, 1997, 35, 3553-3559.

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