Process for synthesizing macrocyclic chelates

Details Process for synthesizing macrocyclic chelates Process for synthesizing macrocyclic chelates

1988-05-25

1990-05-08

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D25700, C07D25900

Patent

active

049239856

ABSTRACT:
A process for synthesizing a 12 membered ring tetraaza macromolecule comprising. The process involves condensing an amide of ethylene diamine having a general formula A: ##STR1## wherein n is an integer from 1 to 5 and w is a member selected from the group consisting of --NO.sub.2, --NH.sub.2, --NCS, --COOH, --OCH.sub.2 OOCH.sub.3, --NCOCH.sub.2 --Z with Z being a member selected from the group consisting of Br and I with a nitrogen blocked active ester of a general formula B: ##STR2## wherein PG is an amino protecting group and E is a leaving group.

REFERENCES:
patent: 2186464 (1940-01-01), Mauersberger
patent: 3979379 (1972-09-01), Siele
patent: 4543213 (1985-09-01), Weitl et al.
patent: 4578517 (1986-03-01), Johnson et al.
Tsuboyama et al., Tetrahedron Letters, No. 16, pp. 1367-1370 (1970).

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