Organic compounds -- part of the class 532-570 series – Organic compounds – Silicon containing
Patent
1994-04-22
1995-07-25
Shaver, Paul F.
Organic compounds -- part of the class 532-570 series
Organic compounds
Silicon containing
556431, 556465, 556482, 556489, 560180, 549 20, 585365, 585446, 585452, 585457, 585505, 585534, C07F 708, C07F 718
Patent
active
054363616
ABSTRACT:
A process for synthesizing enediynes is provided. Specifically, the formed enediynes contain a hex-3-ene-1,5-diynyl group. Production of the enediynes involves adding a base to a propargylic halide in the presence of a chelating agent, which causes a carbenoid coupling-elimination sequence of the propargylic halides. A carbenoid destabilizing agent can also be added to the reaction mixture in order to enhance yield. Acyclic and cyclic enediynes can be synthesized according to this process. The enediynes are useful compounds that can be used in a variety of applications including use in the production of anti-tumor agents.
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Huber Robert S.
Jones Graham B.
Clemson University
Shaver Paul F.
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