Process for synthesizing carbapenem side chain intermediates

Details Process for synthesizing carbapenem side chain intermediates Process for synthesizing carbapenem side chain intermediates

1997-01-14

1998-02-24

McKane, Joseph

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548536, C07D20712, C07D40912

Patent

active

057213682

ABSTRACT:
A process of synthesizing a compound of the formula I: ##STR1## is described. A compound of the formula II: ##STR2## is reacted with diphenylphosphinic chloride to activate the carboxylic acid group, and then reacted with methanesulfonyl chloride to produce a compound of formula IV: ##STR3## Compound IV is then reacted with Na.sub.2 S in water to produce a compound of formula I.

REFERENCES:
patent: 4511576 (1985-04-01), Holland
patent: 5322952 (1994-06-01), Sunagawa et al.
Heterocycles, vol. 41, pp. 147-159 (1995), by H. Matsumura, et al.

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