Process for synthesizing carbapenem intermediates using a rhodiu

Details Process for synthesizing carbapenem intermediates using a rhodiu Process for synthesizing carbapenem intermediates using a rhodiu

1994-01-25

1996-02-20

Cook, Rebecca

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540350, C07D48704, A61K 3140

Patent

active

054930189

ABSTRACT:
This invention relates to the synthesis of a bicyclic ketoester compound of the formula 1 obtained by cyclizing a diazo compound of formula 2: in the presence of a rhodium catalyst. ##STR1## By adding an effective amount of a Lewis acid to the cyclization reaction, the reaction selectively produces the 1-beta methyl isomer, and epimerization of the 1-beta methyl compound to the 1-alpha isomer is minimized.

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