Process for synthesizing beta-lactam

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

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C540S200000, C540S361000

Reexamination Certificate

active

07022842

ABSTRACT:
It is an object of the present invention to provide a method for synthesizing β-lactams and a method for manufacturing β-lactams in water of high-temperature and under high-pressure, and the present invention relates to a β-lactam synthesis method which is characterized in that β-lactams are synthesized by reacting β-amino acids in water at high-temperature and under high-pressure, this method being further characterized in that β-lactams are synthesized at a high speed by cyclizing β-amino acids in water at high-temperature and under high-pressure in which the temperature range is 200° C. or higher and the pressure range is 10 MPa or greater, and the present invention also relates to a method for manufacturing β-lactams which is characterized in that β-lactams are synthesized by reacting β-amino acids in water at high-temperature and under high-pressure, and are then separated and purified using a column separation medium.

REFERENCES:
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Shin-Jikken Kagaku Koza, Yuki Kagobutso no Gosei to Hanno (2), Maruzen, pp. 1197-1201.
J.C. Sheehan et al. Org. React., vol. 9, pp. 388-408 1957.
F.F. Blicke et al. J. Org. Chem., vol. 23, pp. 1102-1107 1958.
T. Kametani et al. Tetrahedron, vol. 36, pp. 715-719 1981.
C.W. Kim et al. Tetrahedron, vol. 31, pp. 2905-2906 1990.

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