Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic halides
Patent
1998-12-22
2000-09-26
Marschel, Ardin H.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic halides
C07C 5158
Patent
active
061245003
ABSTRACT:
A nucleophilic substitution reaction on optionally substituted dihalobenzenes is carried out in the presence of an optional catalyst followed by formation of and subsequent carboxylation of a Grignard reaction intermediate. In particular the present invention provides a process leading to optionally substituted hydroxybenzoic, alkanoyloxybenzoic, formyloxybenzoic and alkoxybenzoic acids from 1-substituted 2,6-dihalobenzenes. The invention also provides a process for the direct formation of an acyl chloride from a Grignard reagent by quenching with phosgene.
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Reaction ID 827509, Beilstein Institut fur Literatur der organischen Chemie (1988-1998) and Justus Liebigs Ann. Chem., vol. 148, p. 222 (1868).
Abdesaken Fereydon
Chong Joshua Anthony
Joshi Sudhir Ramtirth
Spangler Lori Ann
Wu Charles Chao
Carpenter Clark R.
Kafafi Sherif
Marschel Ardin H.
Rohm and Haas Company
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