Process for synthesizing a CETP inhibitor

Details Process for synthesizing a CETP inhibitor Process for synthesizing a CETP inhibitor

2011-01-04

2011-01-04

Nolan, Jason M (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S229000

Reexamination Certificate

active

07863307

ABSTRACT:
An efficient process is disclosed for producing a compound that is an inhibitor of CETP. The last step of the process is the coupling of an oxazolidinone derivative with a biphenyl moiety to provide a compound of formula (I). In a specific embodiment of this synthesis, a crystalline product is produced which is characterized as a non-solvated crystalline polymorph.

REFERENCES:
patent: WO 2006/014357 (2006-02-01), None
patent: WO 2006/014413 (2006-02-01), None
Okamoto et al. Nature Jul. 13, 2000, 406, 203-207.
Schafer et al. (Drug Discovery Today 2008, 13 (21/22), 913-916).
Horig et al. Journal of Translational Medicine 2004, 2(44).

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