Process for synthesizing 4-halo-5-(hydroxymethyl) imidazole comp

Details Process for synthesizing 4-halo-5-(hydroxymethyl) imidazole comp Process for synthesizing 4-halo-5-(hydroxymethyl) imidazole comp

1994-02-14

1996-05-07

Haley, Jacqueline

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23368

Patent

active

055148115

ABSTRACT:
A process for preparing, on an industrial scale, 4-halo-5-(hydroxymethyl) imidazole compounds that are useful as intermediates for medicines. A 4-chloro-5-(hydroxymethyl) imidazole compound, a 4-bromo-5-(hydroxymethyl) imidazole compound or a like compound is synthesized by reacting a 4,5-bis(hydroxymethyl) imidazole compound with a halogenating agent such as an N-chlorosuccinimide, an N-bromosuccinimide, a chlorinated isocyanuric acid compound or the like compound.

REFERENCES:
patent: 4577025 (1986-03-01), Arai et al.
Watson, S. P., "A Convenient Synthesis of 2--Butyl--4(5)--Chloro--1H--Inidazole--5(4)--Carboxaldeh yde," Synthetic Communications, 22(20), 2971-77 (1992).
Shi, Y. et al., "A Practical Synthesis of 2--Butyl--4(5)--Hydroxymethyl--1H--Imidazole", Synthetic Communications, 23(18), 2623-2630, 1993.

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