Process for synthesizing 2-sulphanilamido-3-methoxypyrazine

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

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C07D24122

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042999626

ABSTRACT:
2-Sulphanilamido-3-methoxypyrazine is produced in high purity and good yield, by reacting 2,3-dichloropyrazine with sulphanilamide in the presence of potassium carbonate, an aprotic solvent such as dimethylformamide and a second solvent such as toluene which is inert toward the reagents and is adapted to remove the water of reaction.

REFERENCES:
patent: 3772039 (1973-11-01), Guadagni et al.
Kirk-Othmer, "Encyclopedia of Chemical Technology", vol. 19, 1969, p. 268.

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