Process for synthesis of N-(hydrocarbyl)substituted-p-menthane-3

Details Process for synthesis of N-(hydrocarbyl)substituted-p-menthane-3 Process for synthesis of N-(hydrocarbyl)substituted-p-menthane-3

1981-06-22

1982-12-28

Waltz, Thomas A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544406, 546309, 548200, 549 70, 549480, 564 44, 564123, C07C10200, C07D24100, C07D21300

Patent

active

043663176

ABSTRACT:
This invention provides an improved process for synthesizing carboxamides which involves reacting 3-p-menthyl halide with magnesium to form 3-p-menthylmagnesium halide Grignard reagent, and reacting the Grignard reagent with hydrocarbyl isocyanate at a temperature below about -20.degree. C. to form N-hydrocarbyl-p-menthane-3-carboxamide product.
The product comprises a mixture of geometric isomers in which the 3-p-menthyl:3-p-neomenthyl weight ratio is at least 4:1 and can be as high as 9:1 under optimal conditions.
This invention also provides a novel process for producing acylurea compounds such as N-(3-p-menthylcarbonyl)-N-t-butyl-N'-t-butylurea.

REFERENCES:
patent: 3483248 (1969-12-01), Pattison
patent: 3898073 (1975-08-01), Fitzgerald et al.
patent: 4150052 (1979-04-01), Watson et al.
patent: 4178459 (1979-12-01), Watson et al.
patent: 4193936 (1980-03-01), Watson et al.
patent: 4248859 (1981-02-01), Rowsell et al.
Wagner et al., Synthetic Organic Chemistry, Wiley & Sons, N.Y., N.Y., 1955, pp. 571 & 647.
Singleton et al., JACS 60, pp. 540-543 (1938).

Affiliated with

Also associated with

Rating

Process for synthesis of N-(hydrocarbyl)substituted-p-menthane-3 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for synthesis of N-(hydrocarbyl)substituted-p-menthane-3, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for synthesis of N-(hydrocarbyl)substituted-p-menthane-3 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1338189