Process for synthesis of FK-506 intermediates

Details Process for synthesis of FK-506 intermediates Process for synthesis of FK-506 intermediates

1990-04-11

1992-02-11

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20708

Patent

active

050877038

ABSTRACT:
A process is described for the synthesis of diastereomeric 2-methyl-4-hydroxy-5-protected-hydroxy-hept-6-en-prolinolamides, which are useful as intermediates in the synthesis of the C.sub.10 -C.sub.18 chain of the macrolide structure for the immunosuppressant FK-506. These compounds are also useful as intermediates for preparing lactone ultraviolet radiation absorbers.

REFERENCES:
Evans, et al.; Tetrahedron Letters, 21 (1980), pp. 4233-4236.
Greene, "Protective Groups in Org. Syn", (1981), pp. 293-302; Wiley, N.Y.
Tanaka, et al.; J. Am. Chem. Soc., 109, (1987), pp. 5031-5032.
Askin, et al.; Tetrahedron Letters, 29 (1988), pp. 277-280.
Greger, J. Org. Chem., 37 (1972), pp. 1907-1918.
Iwai, et al.; Bull. Chem. Soc. Japan, 50 (1977), pp. 242-247.
Scheeren, et al.; Tetrahedron Letters, (1979), pp. 2925-2928, No. 31.
Donaubauer; Tetrahedron Letters, (1980), pp. 2771-2772, 21.
Yamaguchi, et al.; Tetrahedron Letters, 25 (1984), pp. 1159-1162.
Brown, et al.; J. Chem. Soc. Chem. Commun. (1985); pp. 1446-1447.
Davies, et al.; Tetrahedron Letters, 26 (1985), pp. 4815-4818.
Hatakeyama, et al.; J. Chem. Soc. Chem. Commun. (1985), pp. 1759-1761.
Hafele, et al.; Angew. Chem. Int. Ed. Engl. 25 (1986) pp. 87-89.
Babine, et al.; Tetrahedron Letters, 27 (1986), pp. 5791-5794.
Schreiber, et al.; J. Am. Chem. Soc.; 109 (1987), pp. 1525-1529.
Dale, et al.; J. Org. Chem., 34 (1969, pp. 2543-2549.
Sonnet, et al.; J. Org. Chem., 45 (1980), pp. 3137-3139.
Denis, et al.; Tetrahedron Letters, 22 (1981), pp. 1429-1430.
Davis, et al.; Tetrahedron Letters, 26 (1985), pp. 3539-3542.
Davis, et al.; J. Org. Chem., 52 (1987), pp. 5288-5290.
Gao, et al.; J. Am. Chem. Soc., 109 (1987), pp. 5765-5780.
Protective Groups in Organic Synthesis, by T. Green, pp. 293-302, [Date not available].
Tetrahedron Letters, vol. 29, No. 34, pp. 4245-4248, (1988), by D. Askin, et al.
Tetrahedron Letters, No. 52, pp. 5175-5178 (1978), by G. Stork, et al.
J. Organic Chemistry, vol. 46, No. 13, pp. 2831-2833, by T. Bruce Grindley, et al., (1981).

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