Process for synthesis of .beta.-phenylalanine

Details Process for synthesis of .beta.-phenylalanine Process for synthesis of .beta.-phenylalanine

1987-03-09

1990-01-02

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 9900

Patent

active

048914428

ABSTRACT:
N-acetyl-.beta.-phenylalanine is synthesized by reacting phenylacetaldehyde, acetamide and synthesis gas with a catalyst comprising a cobalt-containing compound in conjunction with a cocatalyst that may be either a Group VB or VIB containing ligand, or a rhodium compound optionally bonded to one or more Group VB or VIB donor ligands, at a temperature of at least 50.degree. C. and a pressure of at least 500 psi.

REFERENCES:
patent: 3766266 (1973-10-01), Wakamatsu et al.
patent: 3867436 (1975-02-01), Nakamura et al.
patent: 3996288 (1976-12-01), Yukata et al.
patent: 4264515 (1981-04-01), Stern et al.
patent: 4497964 (1985-02-01), Ojima et al.
patent: 4547590 (1985-10-01), Love et al.
Wakamatsu et al., J. Chem. Soc., Chem., Comm, (1971), p. 1560.

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