Process for synthesis of 7-hydroxy coumarins having substitution

Details Process for synthesis of 7-hydroxy coumarins having substitution Process for synthesis of 7-hydroxy coumarins having substitution

1991-05-21

1993-09-21

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D31116

Patent

active

052470997

ABSTRACT:
A process for synthesis of a compound of the formula: ##STR1## said process comprising the steps of (a) reacting 4-bromomethyl-7-methoxy coumarin with a malonic ester under conditions sufficient to achieve condensation of the ester to give the monoalkylated (2-bis(carbalkoxy)-2-R.sub.1 -1-ethyl) derivative; (b) removing one of the carbalkoxy groups from the product of step (a); (c) demethylation of the product of step (b) to give the 7-hydroxycoumarin compound; and (d) chemically modifying the remaining ester to yield a desired R.sub.2.

REFERENCES:
patent: 3933859 (1976-01-01), Kaiser et al.
Brewster/McEven Organic Chemistry 3rd Ed. 1961 pp. 345-347.

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