Process for suppressing graft rejection in organ transplantation

Details Process for suppressing graft rejection in organ transplantation Process for suppressing graft rejection in organ transplantation

1981-06-10

1983-06-14

Lieberman, Allan

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

128 1R, A61K 3170

Patent

active

043883095

ABSTRACT:
Suppression of the immunological rejection mechanism of a host which has received an organ transplant in achieved by the daily administration to the host of a ganglioside agent which effectively blocks the soluble immunological cell mediator interleukin 2 and /or a blastogenic factor. By binding to the mediator for T cell blast formation the mediator is prevented from binding to the asialo GM1 receptor on the surface of the T effector cell. Blastogenesis does not occur and the cell mediated rejection of the graft is prevented.

REFERENCES:
Kasai et al., Nature, vol. 291, pp. 334-335, May 1981.
Kasai et al., Eur. J. Immunol., vol. 10, pp. 175-180, 1980.
Ryan and Shinitzky, Eur. J. Immunol., vol. 9, pp. 171-175, 1979.
Whisler and Yates, J. Immunol, vol. 125, No. 5, pp. 2106-2111, 1980.
Lengle et al., Biol. Abs. 68-035938, 1979.

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