Process for substituting and dequaternizing pyridylethyl quatern

Details Process for substituting and dequaternizing pyridylethyl quatern Process for substituting and dequaternizing pyridylethyl quatern

1977-12-15

1979-06-12

Randolph, John D.

Harness for working animal

546193, 546257, 546258, 546286, 546290, 546301, 546304, C07D21306, C07D21322, C07D40302

Patent

active

041580931

ABSTRACT:
A process for dequaternizing a 2-(2-pyridyl)ethyl or 2-(4-pyridyl)ethyl quaternary salt of a pyridine or bipyridine base comprising the step of heating or reacting the pyridylethyl quaternary salt with a caustic material such as sodium hydroxide. Also included is a process for preparing a second pyridine base (or a bipyridine base) in which a first pyridine base is initially selected and its 2-(2-pyridyl)ethyl or 2-(4-pyridyl)ethyl quaternary salt or its acid salt prepared. An electrophilic, nucleophilic or coupling reaction can then be performed on the quaternary salt to change the substituent or to form the bipyridyl coupling and the resultant salt dequaternized with a caustic material, such as sodium hydroxide, to produce a second pyridine or a bipyridine base.

REFERENCES:
patent: 2512789 (1950-06-01), Cislak et al.
patent: 2742463 (1956-04-01), Finkelstein
patent: 3049547 (1962-08-01), Cislak
Phillips, J. Org. Chem. vol. 14, pp. 302 to 305 (1949).
Kosower et al., J. Am. Chem. Soc., vol. 86, pp. 5524 to 5527 (1964).
Klingsberg, Pyridine and Its Derivatives, Part Two, pp. 24-25, Interscience Publishers Inc. NY (1961).
Klingsberg, Pyridine and Its Derivatives, vol. 12, chapter VII, pp. 368-369.
Baker et al., J. Org. Chem., vol. 20, pp. 118 to 134 (1955).
Berg et al., J. Org. Chem., vol. 41, pp. 2621 to 2624 (1976).
Aumann et al., J. Chem. Soc. Chem. Comm. 1973, pp. 32-33.
Ho et al., J. Am. Chem. Soc., vol. 79, abst. no. 78261m (1973).
Kutney et al., Synth. Commun., vol. 5, pp. 119-124 (1975).

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