Organic compounds -- part of the class 532-570 series – Organic compounds – Cyclopentanohydrophenanthrene ring system containing
Patent
1992-11-05
1994-10-04
Richter, Johann
Organic compounds -- part of the class 532-570 series
Organic compounds
Cyclopentanohydrophenanthrene ring system containing
552558, 552559, 552560, 552561, 552562, 552563, 552564, 552565, 552566, 552567, 552568, 552569, 552570, 552571, 552572, 552573, 552574, 552575, 552576, 552577, 552578, 552579, 552580, 552581, 552582, 552583, 552584, 552585, 552586, 552587, 552589, 552590, 552591, 552592, 552593, 552595, 552596, 552597, 552598, 552599, 552600, 552601, 552602, 552603, 552604, 552605, 552606, 552607, 552608, 552609, 552594, C07J 700, C07J 7500
Patent
active
053528085
ABSTRACT:
A process for the preparation of a compound of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms optionally substituted by halogen or a nitrogen or oxygen function and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.2 is alkyl of 1 to 4 carbon atoms and the A, B, C and D rings are optionally substituted by at least one member of the group consisting of optionally protected --OH or .dbd.0, halogen, alkyl and alkoxy of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms comprising reacting a compound of the formula ##STR2## wherein R.sub.1 and R.sub.2 and the A, B, C and D rings are defined as above with an oxidizing agent in the presence of water and an at least partially water-miscible solvent to obtain a compound of the formula ##STR3## wherein R.sub.1 and R.sub.2 and the A, B, C and D rings are defined as above, subjecting the latter to a solvolysis in a basic or acidic media and optionally subjecting the product to a deprotection reaction of any protected --OH or .dbd.0 groups to obtain the compound of formula I and novel intermediates.
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Buendia Jean
Vivat Michel
Kestler Kimberly J.
Richter Johann
Roussel Uclaf
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