Process for stereoselective reduction of β-ketoesters

Details Process for stereoselective reduction of β-ketoesters Process for stereoselective reduction of β-ketoesters

2007-06-19

2007-06-19

Saeed, Kamal A. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Silicon containing

C558S441000, C560S057000

Reexamination Certificate

active

10483479

ABSTRACT:
In one aspect, the invention provides a process for the preparation of compounds of Formula Iwherein R1is —CN, —OP, alkyl, aryl or heteroaryl; wherein P represents any suitable protecting group; and R2is alkyl or aryl;by reacting a compound of Formula IIwherein R1is —CN, —OP, alkyl, aryl or heteroaryl; wherein P represents any suitable protecting group; and R2is alkyl or aryl;witha reducing agent (e.g. sodium borohydride) in the presence of a metal halid (e.g. CeCl3) or a metal alkoxid (e.g. Ti(OiPr)4).

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