Process for stereoselection of (2R,3S)-3-phenylgycidic ester usi

Details Process for stereoselection of (2R,3S)-3-phenylgycidic ester usi Process for stereoselection of (2R,3S)-3-phenylgycidic ester usi

1993-12-13

1995-04-18

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

4352554, C12P 4100, C12N 116

Patent

active

054078288

ABSTRACT:
The invention relates to the preparation of an optically active ester of trans-3-phenylglycidic acid in which a mixture of the 2 enantiomers of the trans-3-phenylglycidic acid ester is stereoselectively hydrolyzed using an enzyme originating from Candida antarctica and the non-hydrolyzed ester is separated off from the reaction mixture.
A racemic mixture of trans-phenylglycidic acid esters is selectively and enzymatically hydrolyzed in a relatively short reaction time, the residual ester being obtained in a high yield and with a high e.e. Such esters are used for the preparation of pharmaceuticals such as benzothiazepines and benzazepines.

REFERENCES:
patent: 5156963 (1992-10-01), Eigtved
patent: 5169779 (1992-12-01), Zard et al.
patent: 5273898 (1993-12-01), Ishii

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