Process for stabilizing therapeutic compositions and article

Details Process for stabilizing therapeutic compositions and article Process for stabilizing therapeutic compositions and article

1975-03-07

1976-11-23

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

424153, 424154, 424156, 424161, A61K 3310, A61K 3314, A61K 3342

Patent

active

039937518

ABSTRACT:
A stabilized, therapeutic composition is provided which comprises an aqueous medium containing known amounts of Na.sup.+, K.sup.+, HCO.sub.3 .sup.-, and Cl.sup.- wherein the pH of the solution is maintained between about 6 and 8.5 and the osmolality is maintained between about 170 and 460 by maintaining a gaseous mixture as a blanket over the solution during manufacture and storage, the gaseous mixture containing a sufficient amount of carbon dioxide to substantially equal the partial pressure of the carbon dioxide produced from equilibrium within the solution.

REFERENCES:
patent: 1616202 (1927-02-01), Shook
Verbruggen, Chem. Abst., vol. 72 (1970), p. 99376y.

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