Process for stabilizing liposomes

Details Process for stabilizing liposomes Process for stabilizing liposomes

1989-11-22

1992-03-10

Lovering, Richard D.

Plastic and nonmetallic article shaping or treating: processes

Encapsulating normally liquid material

Liquid encapsulation utilizing an emulsion or dispersion to...

264 41, 264 46, 424 943, 424450, 425 5, 436829, A61K 9127, A61K 9133

Patent

active

050947850

ABSTRACT:
The present invention relates to a process for forming stable, uniform unilamellar or oligolamellar liposomes which encapsulate a macromolecule. However, unlike prior processes, the present method maintains a temperature below the phase transition temperature of the lipid used to make the liposome both during the hydration of the lipid and, if used, during an extrusion step. In addition, the liposome is formed and the macromolecule encapsulated in a low ionic strength solution, then they are dialyzed against a high ionic strength solution.

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