Process for stabilization of bacampicillin hydrochloride

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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540315, 540336, A61K 3143, C07D49932

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active

046265325

ABSTRACT:
A new process for the stabilization of bacampicillin hydrochloride against degradation by humidity characterized by the incorporation of between 3 to 9% by weight of straight-chain alkanes, alkenes, fatty acids, alcohols, and esters of fatty acids and alcohols with molecular weights between 144 and 350, which may be carried out in one step together with wetmassing for granulation.

REFERENCES:
patent: 3939270 (1976-02-01), Ekstrom et al.
Chemical Abstracts, vol. 55 (1961), abstract No. 20,339b, Czech. 96,618, "Antibiotic Preparations".
Chemical Abstracts, vol. 93 (1980), abstract No. 245,445x, Pol. 106,789, "Stabilization of 6-[D(-).alpha.(aminophenyl)acetamido]penicillanic Acid Trihydrate".
Chemical Abstracts, vol. 94 (1981), abstract No. 20,395b, Jpn. Kokai Tokkyo Koho 80 87,715, "Stabilized Bacampicillin Hydrochloride Preparations".

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