Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1991-06-27
1992-08-25
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514289, 514420, 514343, 514357, 514548, 514570, 514648, 514653, 514718, 514772, A61K 3144, A61K 3140, A61K 31225, A61K 3119, A61K 31135, A61K 31075
Patent
active
051419610
ABSTRACT:
The present invention relates to a process for solubilizing at least one difficultly soluble pharmaceutical active in a mixture of polyethylene glycol and polyvinylpyrrolidone. The process does not require water as a solvent or the use of a heating step. In further embodiments, the present invention also relates to a process for encapsulating these solubilized pharmaceutical compositions within soft gelatin shells, which are preferably transparent. Both the resulting compositions and their capsules provide an effective means for oral delivery of a wide variety of difficultly soluble pharmaceutical actives.
REFERENCES:
patent: 3851051 (1974-11-01), Miskel et al.
patent: 4067960 (1978-01-01), Fadda
patent: 4198391 (1980-04-01), Grainger
patent: 4690823 (1987-09-01), Lohrer et al.
patent: 4744988 (1988-05-01), Brox
patent: 4764378 (1988-08-01), Keith et al.
patent: 4780316 (1988-10-01), Brox
patent: 4820522 (1989-04-01), Radebaugh et al.
patent: 4857312 (1989-08-01), Hegasy et al.
patent: 4888239 (1989-12-01), Brox
patent: 4968509 (1990-11-01), Radebaugh et al.
patent: 5006595 (1991-04-01), Smith et al.
D. Q. M. Craig, "Polyethylene Glycols and Drug Release", Drug Dev. and Industrial Pharmacy, 16(17), pp. 2501-2526 (1990).
J. E. Hilton et al., "The Effect of Wetting Agents on the Dissolution of Indomethacin Solid Dispersion Systems", Int J of Pharm, 31 pp. 157-164, (1986).
L. Lachman et al., "Soft Gelatin Capsules", The Theory and Practice of Industrial Pharmacy, (Lea & Febiger, Phil.) pp. 398-412 (1986).
H. Seager, "Soft Gelatin Capsules: A Solution to Many Tableting Problems", Pharmaceutical Technology, Sep. 1985.
RP Sherer Technical Data Bulletin, "Scherersol.TM. The Best Solution for Better Drug Absorption".
Dabbiere David K.
Jordan Kimberly
Mohl Douglas C.
Richrdson-Vicks Inc.
Sabatelli Anthony D.
LandOfFree
Process for solubilizing difficulty soluble pharmaceutical activ does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for solubilizing difficulty soluble pharmaceutical activ, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for solubilizing difficulty soluble pharmaceutical activ will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-385397