Single-crystal – oriented-crystal – and epitaxy growth processes; – Processes of growth from liquid or supercritical state – Having growth from a solution comprising a solvent which is...
Patent
1995-11-01
1998-09-08
Bawa, Raj
Single-crystal, oriented-crystal, and epitaxy growth processes;
Processes of growth from liquid or supercritical state
Having growth from a solution comprising a solvent which is...
424489, 117925, G30B 700, A61K 914
Patent
active
058039660
ABSTRACT:
A process employing a supercritical fluid anti-solvent for sizing prednisolone acetate is disclosed. The process optionally incorporates sterilization filters. Average particle sizes of about 1 .mu.m or less (number average) and narrow particle size ranges are obtainable. The process comprises the steps of (a) forming a solution by dissolving prednisolone acetate in acetone such that the concentration of prednisolone acetate is approximately 80% or less of its solubility in acetone; and (b) transporting the solution formed in step (a) through an orifice having a diameter of 50-100 .mu.m into a mixer/expander containing compressed CO.sub.2, wherein the compressed CO.sub.2 is at a temperature from about 40.degree. to 80.degree. C. and has a density less than the density of the solution by at least 0.3 g/cc, to expand the solution so that the acetone dissolves in the CO.sub.2 and the prednisolone acetate precipitates.
REFERENCES:
patent: 4263253 (1981-04-01), Pilz et al.
patent: 4582731 (1986-04-01), Smith
patent: 5043280 (1991-08-01), Fischer et al.
patent: 5360478 (1994-11-01), Krukonis et al.
Bodmeier et al., "Polymeric Microspheres Prepared by Spraying into Compressed Carbon Dioxide," Pharmaceutical Research, vol. 12(8), pp. 1211-1217, 1995.
Dixon et al., "Polymeric Materials formed by Precipitation with a Compressed Fluid Antisolvent," AIChE Journal, vol. 39(1), pp. 127-139, 1993.
Donsi et al., "Micronization by Means of Supercritical Fluids: Possibility of Application to Pharmaceutical Field," Pharm. Acta Helv., vol. 66(5-6), pp. 170-173, 1991.
Gallagher et al., "Gas Antisolvent Recrystallization: New Process to Recrystallize Compounds Insoluble in Supercritical Fluids," ACS Symposium Series 406, American Chemical Society: Washington, D.C. pp. 334-354, 1989.
Gallagher et al., "Gas Anti-Solvent (Gas) Recrystallization: Application to Particle Design," AIChE Symposium Series, vol. 87, No. 284, pp. 96-103, 1991.
Gallagher-Wetmore et al., "Recrystallization Using Supercritical Fluids: Novel Techniques for Particle Modification," First International Particle Technology Forum, Aug. 17-19, 1994, Denver, Colorado, American Institute of Chemical Engineers.
Gallagher-Wetmore et al., "Application of Supercritical Fluids in Recrystallization: Nucleation and Gas Anti-Solvent (Gas) Techniques," Respiratory Drug Delivery, IV, pp. 287-295, 1994.
Larson et al., "Evaluation of Supercritical Fluid Extraction in the Pharmaceutical Industry," Biotechnology Progress, vol. 2(2), p. 73, 1986.
Mohamed et al., "Effects of Process Conditions on Crystals Obtained from Supercritical Mixtures," AIChE Journal, vol. 35(2), pp. 325-328, 1989.
Mulcahey et al., "Supercritical Fluid Extraction of Active Components in a Drug Formulation," Anal. Chem., vol. 64, pp. 981-984, 1992.
Randolph et al., "Sub-Micron Sized Biodegradable Particles of Poly(L-Lactic Acid) via the Gas Antisolvent Spray Precipitation Process," Biotechnology Progress, vol. 9 (4), pp. 429-435, 1993.
Yeo et al., "Production of Microparticulate Protein Powders Using a Supercritical Fluid Anti-Solvent," Biotech. Bioeng., vol. 41, pp. 341-346, 1993.
Anderson Scott D.
Krukonis Val J.
Kulshreshtha Alok K.
Smith Garnet G.
Alcon Laboratories Inc.
Bawa Raj
Ryan Patrick M.
LandOfFree
Process for sizing prednisolone acetate using a supercritical fl does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for sizing prednisolone acetate using a supercritical fl, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for sizing prednisolone acetate using a supercritical fl will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1278055