Process for simultaneously removing tumour necrosis factor .alph

Liquid purification or separation – Processes – Making an insoluble substance or accreting suspended...

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210650, 210651, 210660, 210669, 210724, 210725, 210729, 210730, 210749, 210767, 210782, 436177, 436178, 530412, 530414, 530415, 530416, 530417, 530418, 530419, 604 4, 604 5, C07K 114, C07K 130, C07K 134, A61M 134

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056792603

ABSTRACT:
Disclosed is a process to remove tumour necrosis factor .alpha. (TNF.alpha.) or/and bacterial lipopolysaccharides (LPS) from an aqueous liquid, in particular blood, blood plasma or serum, in an extracorporeal perfusion system after removing corpuscular blood components if necessary, wherein
(a) the pH value of the body fluid is adjusted to pH<6,
(b) a precipitation reagent in the form of a polyanion is added,
(c) precipitated substances are removed by filtration or/and centrifugation and
(d) the resulting liquid is passed over an anion exchanger.

REFERENCES:
patent: 4648974 (1987-03-01), Rosskopf et al.
patent: 4908354 (1990-03-01), Seidel et al.
patent: 4923439 (1990-05-01), Seidel et al.
patent: 4935204 (1990-06-01), Seidel et al.
patent: 5403917 (1995-04-01), Boos et al.

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