Process for separation of sulfated glycosaminoglycans

Details Process for separation of sulfated glycosaminoglycans Process for separation of sulfated glycosaminoglycans

1990-01-03

1992-05-26

Nutter, Nathan M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C08B 3400, C08B 3402, C08B 3708, C08B 3710

Patent

active

051169665

ABSTRACT:
The present invention relates to a process for purifications of natural or synthetic polymers in solution, water-soluble or soluble in water-alcohol medium and comprising sulfate groups, the process consisting essentially, on the one hand, of a selective precipitation in which the sulfated polymers to be purified are complexed in acid medium with a polyamine insoluble at a pH greater than 7 and, on the other hand, after isolation of the complex thus formed, of a progressive solubilizing of the sulfated polymers.

REFERENCES:
patent: 3909405 (1975-09-01), Aoyama
Grant et al., "Grant and Hackh's Chemical Dictionary", 5th ed. p. 516.
Chemical Abstracts Nos. 88:184937g, Jun. 19, 1978, p. 271.
Yasuo Kikuchi, "Polyelectrolyte Complex of Heparin with Chitosan", Die Makromolekulare Chemie, vol. 175, 1974, pp. 2209-2211.

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