Chemistry: molecular biology and microbiology – Process of utilizing an enzyme or micro-organism to destroy... – Resolution of optical isomers or purification of organic...
Patent
1994-01-12
1995-05-30
Naff, David M.
Chemistry: molecular biology and microbiology
Process of utilizing an enzyme or micro-organism to destroy...
Resolution of optical isomers or purification of organic...
435876, 435121, C12P 4100, C12P 1710
Patent
active
054200377
ABSTRACT:
S-enantiomers of the formula ##STR1## result from the reaction of a racemic form of compound I with an alcohol in the presence of an enzyme capable of selectively esterifying the R-enantiomers of the racemic compound.
REFERENCES:
patent: 4105776 (1978-08-01), Ondetti et al.
patent: 4601987 (1985-07-01), Klibanov et al.
patent: 4629701 (1986-12-01), Sakimae et al.
B. Cambou et al., Biotechnology and Bioengineering, vol. XXVI, pp. 1449-1454 (1984).
Howell Jeffrey M.
Patel Ramesh N.
Szarka Laszlo J.
E. R. Squibb & Sons Inc.
Furman Jr. Theodore R.
Naff David M.
Park Ellen K.
Saucier S.
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