Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1996-12-06
1998-04-28
Lilling, Herbert J.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
424646, 210656, A01N 6500, A01N 5916, B01D 1508
Patent
active
057441383
ABSTRACT:
The present invention provides a process for separating organogermanium and inorganogermanium compounds from a germanium-containing pharmaceutical plant or its processed products by applying the extract of a germanium-containing pharmaceutical plant or its processed products into a combination column including a cation exchange resin in the lower part of the column and an anion exchange resin in the upper part of the column, eluting the combination column with deionized water to obtain inorganogermanium solution, then with an alkaline solution to release the organogermanium compounds, and finally with deionized water to obtain organogermanium solution. The present invention also provides a process for determining the total germanium, organogermanium, inorganogermanium content of a germanium-containing pharmaceutical plant or its processed products by ICP-AES.
REFERENCES:
patent: 3787317 (1974-01-01), Jaworek
Chiang et al., "Germanium Enriched Ganoderma lucidum and Its Germanium Content", The Chinese Pharmaceutical Journal, pp. 339-344, vol. 41, No. 4.
Chiang et al., "Improved Method of Assay for Germanium in Crude Drugs", Journal of the Taiwan Pharmaceutical Association, vol. 38, No. 3, (1986).
Chien, et al., "Studies on Ganoderma spp. Cultured in Germanium-enriched Liquid Media", The Chinese Pharmaceutical Journal, vol. 42, No. 4 (1990).
Itano, et al., "Analysis of Germanium Compounds in Health Beverage", pp. 231-237, vol. 33, No. 3, (1992).
Kakimoto et al., "Organogermanium Compounds: Synthesis, Structure, and Properties of Masked Carboxyethylgermanium Sesquioxide (GE-132) and Related Compounds with One Triethanolamine Component", Heterocycles, pp. 347-353, vol. 26, No. 2 (1987).
Tao, et al., "Determination of Germanium, Arsenic, Antimony, Tin and Mercury at Trace Levels by Continuous Hydride Generation-Helium Microwave-Induced Plasma Atomic Emission Spectrometry", Analytical Sciences, pp. 55-59, vol. 7.
Food Industry Research & Development Institute
Lilling Herbert J.
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