Process for separating optically active 1-hydroxy-cyclopentane m

Details Process for separating optically active 1-hydroxy-cyclopentane m Process for separating optically active 1-hydroxy-cyclopentane m

1994-10-13

1996-02-27

Marx, Irene

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435874, 435921, C12P 4100

Patent

active

054948215

ABSTRACT:
In the present invention, an optically active cis type 1,2-diol derivative of the following formula (I) is produced by reacting a cis type 1,2-diol derivative of the formula (I) with a carboxylic acid derivative of the formula (II) in the presence of a lipase: ##STR1## wherein R.sup.1 and R.sup.2 independently represent hydrogen atom or an alkyl group, X represents a halogen atom, a nitro group, a cyano group, an alkyl group, a haloalkyl group, or a phenyl group, and n represents an integer of from 0 to 5; R.sup.3 represents a C.sub.1 -C.sub.10 alkyl group or an aryl group, and R.sup.4 represents a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group, a C.sub.2 -C.sub.4 alkenyl group, or COR.sub.3.
The cis type means that the bond between the cyclopentane ring and the hydroxy group and the bond between the cyclopentane ring and the benzyl group reside in the same direction as that portrayed on the paper.
The optically active cis type 1,2-diol derivative is used as an intermediate for producing an optically active cis type azole derivative of the formula (VII).

REFERENCES:
patent: 4607013 (1986-08-01), Mitsuda et al.
patent: 4933290 (1990-06-01), Cesti et al.
patent: 5142061 (1992-08-01), Briner
patent: 5225430 (1993-07-01), Minoguchi et al.
Jones JB, Tetrahedron 42:3351-3403 (1986).
Chemical Abstracts, vol. 107(23), 214288b, 1987.
Chemical Abstracts, vol. 107(13), 111964q, 1987.
Chemical Abstracts, vol. 103(25) 210372u, 1985.

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