Process for separating and producing chlorogenic acid

Details Process for separating and producing chlorogenic acid Process for separating and producing chlorogenic acid

1989-03-20

1989-10-10

Therkorn, Ernest G.

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210656, 426422, B01D 1508

Patent

active

048729876

ABSTRACT:
Chlorogenic acid can be separated and produced as free acid or as salts thereof from plant raw material extracts by means of gel permeation chromatography on cross-linked modified polysaccharides, especially on dextrans. To obtain the free acid, the aqueous extract must be adjusted to a pH in the range of about 2 to 2.8. By use of a column of sufficient length the isomeric 5-, 4- and 3-chlorogenic acid can also be separated by the process of the invention.

REFERENCES:
patent: 3502545 (1970-03-01), Westman
patent: 3664845 (1972-05-01), Friedman
patent: 4113887 (1978-09-01), Keamer
patent: 4113888 (1978-09-01), Henig
patent: 4130556 (1978-12-01), Wachter
patent: 4278696 (1981-07-01), Magnolato
patent: 4426292 (1984-01-01), Wernick
patent: 4714555 (1987-12-01), Shibata
Laffanzio, Determination of Plant Phenol by Gel Filtration, Journal of Food Science, vol. 46, (1981), pp. 1907-1909 and 1917.
Mikes' Laboratory Handbook of Chromatographic and Allied Methods, Ellis Horwod Limited, 1979, pp. 399 & 370.
Snyder, Introduction to Modern Liquid Chromatography, Second Editions, 1979, John Wiley & Sons, p. 723.
The Merck Index, Tenth Edition, Merck & Co., 1983, p. 217.

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