Process for separating a radionuclide from solution

Chemistry of inorganic compounds – Treating mixture to obtain metal containing compound – Radioactive metal

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423 215, 423 24, C01F 100

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active

054096774

ABSTRACT:
A process for separating a radionuclide such as radioactive Cu-64 from a mixture containing the radionuclide and a precursor element from which the radionuclide is formed. A weak acid solution is prepared which contains the mixture of the radionuclide and the element. The solution is contacted with a ligand which preferentially forms a complex with the radionuclide relative to the precursor element. The radionuclide complexed to the ligand is separated from the precursor element and released from the ligand by contacting the ligand with an acid.

REFERENCES:
patent: 3957945 (1976-05-01), Grant et al.
patent: 4487738 (1984-12-01), O'Brien, Jr. et al.
patent: 4563256 (1986-01-01), Sudderth et al.
patent: 4756904 (1988-07-01), Crook
patent: 4816233 (1989-03-01), Rourke et al.
patent: 4898719 (1990-02-01), Rourke et al.
patent: 4968504 (1990-11-01), Rourke
patent: 5019362 (1991-05-01), Rourke et al.
Zinn et al., Antibody, Immunoconjugates, and Radiopharmaceuticals, vol. 5, No. 3, 1992; Sep. 11, 1992.
Zinn et al., J. Nucl. Medicine, Aug. 27, 1992.
Research Scale Chromatography (Bio Rad); pp. 97-108.
Bio Rad Chelex Instruction Manual; pp. 2-15.
1990 Bio Rad Price List; pp. 24-35.
1991 Bio Rad Price List; pp. 1-8.
Bhatki, et al., 63078x, Preparation of Carrier-free copper-64,67 nuclides by liquid-liquid extraction, Chemical Abstracts, vol. 70, 1969, p. 424.
Toth, et al., 136273f, Separation of carrier-free copper-64 and (or) copper-67 from reactor irradiated zinc by means of the spontaneous deposition of copper on platinum black; Nuclear Phenomena, vol. 73, 1970, p. 395.
Mirzadeh, et al., 118:68546t, Spontaneous electrochemical separation of carrier-free copper-64 and copper 67 from zinc targets, Nuclear Technology, vol. 118, 1993, p. 579.
Gelis, 34632a, Marcoaggregates of copper-64 and geletin, Pharmaceuticals, vol. 74, 1971, p. 207.
Gelis, 49974d, Gelatin copper-64 marcroaggregates, Chemical Abstracts, vol. 76, 1972, p. 278.
Gelis, 168660d, Colloidal cuprous Cu-64 oxide for liver scintigraphy, Pharmaceuticals, vol. 77, 1972, p. 271.
F. Dyer, et al., The Radiochemistry of Copper, Nat. Academy of Sciences, 1961.
Chikuma, et al., Chelate-Forming Resins Prepared by Modification of Anion-Exchange Resins, Talanta, 1980, vol. 27, pp. 807-810.
G. Schmuckler, An Analytical Approach to Chelating Resins, Talanta, 1963, vol. 10, pp. 745-751.
H. Loewenschuss, et al., Chelating Properties of the Chelating Ion Exchanger Dowex A-1, Talanta, 1964, vol. 11, pp. 1399-1408.
S. Mirzadeh, et al., Production of No-Carrier Added 67Cu, Appl. Radiat. Isot., vol. 37, No. 1, pp. 29-36, 1986.
K. Fritze, The Preparation of High Specific Activity Copper 64, Radiochimica Acta, 1964, p. 166.
G. Bormans, et al., A 62Zn/62Cu Generator for the Routeine Production of 62Cu-PTSM, Appl. Radiat. Isot., vol. 43, No. 12, pp. 1437-1441, 1992.
E. L. Hetherington, et al., The Preparation of High Specific Activity Copper-64 for Medical Diagnosis, Appl. Radiat. Isot., vol. 37, No. 12, pp. 1242-1243, 1986.
C. Mathias, et al., Evaluation of a Potential Generator-Produced PET Tracer for Cerebral Perfusion Imaging: Single-Pass Cerebral Extraction Measurements and Imaging with Radiolabeled Cu-PTSM, J. Nucl. Med. 1990, 31:351-359.
C. Anderson, et al., Copper-64-Labeled Antibodies for PET Imaging, J. Nucl. Med. Sep. 1992, 33:1685-1691.
K. Burger, Analytical Use of 1,3-Dimethyl-4-imino-5-oximinoalloxan-1, Talanta, 1961, vol. 8, pp. 77-84.
K. Brajter, et al., Preconcentration and Separation of Metal Ions by Means of Amerlite XAD-2 Loaded with Pyrocatechol Violet, Talanta, vol. 35, No. 1, pp. 65-67, 1988.
Y. Sakai, Photometric Determination of Copper with N-(Dithiocarboxy)Sarcosine After Preconcentration with Amberlite XAD-2 Resin, Talanta, 1980, vol. 27, pp. 1037-1076.
D. Ryan, Comparison of Chelating Agents Immobilized on Glass with Chelex 100 for Removal and Preconcentration of Trace Copper(II), Talanta, vol. 32, No. 9, pp. 859-863, 1985.
J. Adam, et al., Analytical Use of the Selective Extraction of Copper as its Phenylacetate, Talanta, 1972, vol. 19, pp. 1105-1111.
A. Reddy, et al., Sequential Extraction and Determination of Copper and Nickel with 2,4-Dihydroxyacetophenone Thiosemicarbazone, Talanta, vol. 33, No. 7, pp. 617-619, 1986.
M. Khuhawar, et al., High Performance Liquid Chromatographic Determination of Copper(II) and Nickel(II) by Using Solvent Extraction and Bis(Acetylpivalylmethane)Ethylenediimine as Complexing Reagent, Talanta, vol. 39, No. 6, pp. 609-612, 1992.
J. Hibbits, et al., The Analysis of Beryllium and Beryllium Oxide-II, Talanta, 1960, vol. 4, pp. 101-103.
The Merck Index, 10th Edition, 1983.
A. Dasgupta, et al., A New Separation Procedure for 67Cu from Proton Irradiated Zn, Appl. Radiat. Isot., vol. 42, No. 4, pp. 371-376, 1991.
Zinn, Fourth Conference on Radioimmunodetection and Radioimunotherapy of Cancer, Princeton, N.J., Sep. 16, 1992.
Zinn, Society of Nuclear Medicine Annual Meeting, Jun. 8-Jun. 11, 1993, Toronto, Canada.

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