Process for selectively producing an (S)-9-fluoro-3-methyl-10-(4

Details Process for selectively producing an (S)-9-fluoro-3-methyl-10-(4 Process for selectively producing an (S)-9-fluoro-3-methyl-10-(4

1994-01-18

1996-08-13

Daltow, Philip I.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C07D49806, C07D49816

Patent

active

055457371

ABSTRACT:
A process for selectively producing an (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3 -dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid hemihydrate or monohydrate as depicted below, which comprises controlling the water content of an aqueous solvent in which an (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazin -yl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid is dissolved during a crystallization. ##STR1##

REFERENCES:
patent: 4382892 (1983-05-01), Hayakawa et al.
patent: 4607046 (1986-08-01), Morita et al.
patent: 4628111 (1986-12-01), Masmiba et al.
patent: 5053407 (1991-10-01), Hayakawa et al.
patent: 5098911 (1992-03-01), Ibrahim
"Techniques And Experiments for Organic Chemistry" by Ault pp. 55-58, 142-146. (1983).

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