Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1990-06-25
1993-05-11
Marx, Irene
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435118, 435136, 435198, C12P 1718, C12P 1716, C12P 740, C12N 920
Patent
active
052100308
ABSTRACT:
Described is a new process for selectively acylating FK-506 type immunosuppressant macrolides, including immunomycin (FK-520), in the C-32 position, under novel conditions utilizing an immobilized lipase enzyme, an acyl donor, and a dry, non hydroxylic organic solvent. The enzyme is absorbed onto a solid support and the enzyme/support catalyzes the C-32 acylation. The enzyme/support complex can then be filtered from the reaction mixture and, recycled for use.
REFERENCES:
patent: 3244592 (1966-05-01), Arai
patent: 4894366 (1990-01-01), Okuhara et al.
Bianchi et al., J. Org. Chem., vol. 53, pp. 5531-5534, 1988.
J. Antibiotics, A15, pp. 231-232, by Arai, et al.
Arison Byron H.
Chen Shieh-Shung T.
Petuch Brian R.
Caruso Charles M.
Marx Irene
Merck & Co. , Inc.
Mitri Salvatore C.
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