Process for selecting anti-sense oligonucleotides

Details Process for selecting anti-sense oligonucleotides Process for selecting anti-sense oligonucleotides

1998-02-23

2000-05-09

Brusca, John S.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C12Q 168

Patent

active

060602481

ABSTRACT:
Methods for identifying a site on a nucleic acid sequence having a desired free energy variability are disclosed. The methods are useful for, e.g., selecting antisense oligonucleotides, e.g., for therapeutic use.

REFERENCES:
patent: 5496698 (1996-03-01), Draper et al.
patent: 5525468 (1996-06-01), McSwiggen
Hyndman et al. Software to determine optimal oligonucleitide sequences based on hybridization simulation data. Biotechniques vol. 20 pp. 1090-1096, 1996.
Crooke, S.T., "Progress Toward Oligonucleotide Therapeutics: Pharmacodynamic Properties," FASEB J., vol. 7, pp. 533-539 (1993).
Kawasaki, A.M. et al., "Uniformly Modified 2'-Deoxy-2'-fluoro Phosphorothioate Oligonucleotides as Nuclease-Resistant Antisense Compounds with High Affinity and Specificity for RNA Targets," J. Med. Chem., vol. 6, No. 7, pp. 831-841 (1993).
Monia, B.P. et al., "Evaluation of 2'-Modified Oligonucleotides Containing 2'-Deoxy Gaps as Antisense Inhibitors of Expression," J. Biol. Chem., vol. 268, No. 19, pp. 14514-14522 (1993).

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