Process for selecting an enantiomer of a hydroxy lactone using p

Details Process for selecting an enantiomer of a hydroxy lactone using p Process for selecting an enantiomer of a hydroxy lactone using p

1993-03-24

1995-05-09

Knode, Marian C.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435874, 435876, 435877, C12P 4100

Patent

active

054139350

ABSTRACT:
An enantiomerically pure compound of the formula ##STR1## is prepared when the associated racemic mixture is reacted with an acrylating agent R.sup.3 --C(O)--O--R in the presence of a microorganism or enzyme derived therefrom capable of catalyzing transesterification of an alcohol. X.sup.1 and X.sup.2 are each independently halogen, R is alkyl, R.sup.1 and R.sup.2 are each independently alkyl, cycloalkyl, aralkyl or aryl and R.sup.3 is alkyl, cycloalkyl, aryl or aralkyl.

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