Process for screening of a binding peptide specific for...

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence

Reexamination Certificate

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C530S323000, C506S009000, C506S018000, C435S006120, C435S007100

Reexamination Certificate

active

07999070

ABSTRACT:
The present invention relates to a screening method for RNA specific binding peptide using alpha-helical peptides. The screening method for RNA specific binding peptide of the present invention using alpha-helical peptides enables the selection of a peptide having strong binding capacity to a specific RNA having particular morphology and nucleotide sequence and the investigation of functions of RNA using the selected peptides, and is very useful for the production of a new drug using synthetic peptide having more powerful and specific binding capacity to RNA than those of natural peptides.

REFERENCES:
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patent: 6943001 (2005-09-01), Zhao et al.
patent: WO 2006/135045 (2006-12-01), None
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Watanabe et al., 2005, Anomalous reflection of gold applicable for a practical protein-detecting chip platform, Molecular BioSystems, 1: 363-365.
Lawton and Appella, “Nonionic Side Chains Modulate the Affinity and Specificity of Binding Between Functionalized Polyamines and Structured RNA,” J. Am. Chem. Soc. 126: 12762-12763 (2004).
Das and Frankel, “Sequence and Structure Space of RNA-Binding Peptides,” Biopolymers, 70: 80-85 (2003).
Tan and Frankel, “Structural Variety of Arginine-Rich RNA-Binding Peptides,” Proc. Natl. Acad. Sci. USA, 92: 5282-5286 (1995).
Liu and Dreyfuss, “In Vivo and In Vitro Arginine Methylation of RNA-Binding Proteins,” Molecular and Cellular Biology, 15(5): 2800-2808 (1995).

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