Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving blood clotting factor
Patent
1998-04-29
1999-08-31
Fonda, Kathleen K.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving blood clotting factor
436 69, 436172, 424529, 424531, 424532, 530381, 530382, C12Q 156, G01N 3386, G01N 3348, G01N 2176
Patent
active
059452978
ABSTRACT:
The present invention provides a method for screening candidate agents to identify compounds that modulate the hemostatic system. The method of the invention involves a screening medium comprised of stored whole blood, preferably diluted with buffer, to which unrefrigerated platelets have been added. Candidate agents that may inhibit or activate clot formation or clot lysis are added to the screening medium and suitable compounds are identified. The assay provided is physiologically relevant, rapid, inexpensive and allows for large scale screening of candidate agents.
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Fonda Kathleen K.
Francis Carol L.
MetaXen LLC
Moran Marjorie
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