Process for scaled-up production of recombinant proteins...

Chemistry: molecular biology and microbiology – Plant cell or cell line – per se ; composition thereof;... – Plant cell or cell line – per se – contains exogenous or...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S420000, C435S431000, C800S320200

Reexamination Certificate

active

07045354

ABSTRACT:
The present invention relates to methods for semi-continuous culture of plant cells in a nutrient medium. The pH of the medium is monitored during the cell culture as a way of monitoring the expression of a product of interest by the cells.

REFERENCES:
patent: 4064015 (1977-12-01), Nyiri et al.
patent: 5407816 (1995-04-01), Bringi et al.
patent: 5693506 (1997-12-01), Rodriguez
patent: 6127145 (2000-10-01), Sutliff et al.
patent: WO 95/14099 (1995-05-01), None
Des Molles, D.V. et al., “Expression of a Carrot Invertase Gene in Tobacco Suspension Cells Cultivated in Batch and Continuous Culture Conditions,”Journal Bioscience Bioeng.,87:302-306 (1999).
Fischer, U. et al., “Semicontinuous cultivation of photoautotrophic cell suspension cultures in a 20 I airlift-reactor,”Plant Cell, Tissue and Organ Culture, 38:123-134 (1994).
Huang, N. et al., Metabolic regulation of α-amylase gene expression in transgenic cell cultures of rice (Oryza sativaL.),Plant Molecular Biology, 23:737-747 (1993).
Huang, N. et al., “Structural organization and differential expression of rice α-amylase genes,”Nucleic Acids Research, 18(23):7007-7014 (1990).
Moorhouse, S.D. et al., “A plant cell bioreactor with medium-perfusion for control of somatic embryogenesis in liquid cell suspensions,”Plant Growth Regulation, 20:53-56 (1996).
Ozturk, S.S., “Engineering challenges in high density cell culture systems,”Cytotechnology, 22:3-16 (1996).
Phisalaphong, M. and Linden, J.C., “Kinetic Studies of Paclitaxel Production byTaxus canadensisCultures in Batch and Semicontinuous with Total Cell Recycle,”Biotechnol. Prog.,15:1072-1077 (1999).
Ryland, J.R. et al., “Effect of Gelatin on the Stability of Heavy Chain Monoclonal Antibody Production from Plant Suspension Cultures,”J. Microbiol. Biotechnol.10(4):449-454 (2000).
Scragg, A.H. et al., “Growth ofCatharanthus roseussuspensions for maximum biomass and alkaloid accumulation,”Enzyme Microb. Technol.,12:292-298 (1990).
Seki, M. et al., “Taxol (Paclitaxe) Production Using Free and Immobilized Cells of Taxus cuspidata,”Biotechnology and Bioengineering., 53(2):214-219 (1997).
Su, W.W. and Lei, F., “Perfusion Strategy for Rosmarinic Acid Production byAnchusa officinalis,” Biotechnology and Bioengineering, 42(7):884-890 (1993).
Su, W.W. et al. “High density cultivation ofAnchusa officinalisin a stirred-tank bioreactor with in situ filtration,”Appl. Microbiol, Biotechnol.,44:293-299 (1995).
Su, W.W. et al., “A perfusion air-lift bioreactor for high density plant cell cultivation and secreted protein production,”Journal of Biotechnology, 50:225-233 (1996).
Ten Hoopen, H.J.G. et al., “Continuous Culture of Suspended Plant Cells,”In Vitro Cell Dev. Biol.,28P: 115-120 (1992).
Terashima, M. et al., “Effects of sugar concentration on recombinant human α1-antitrypsin production by genetically engineered rice cell,”Biochemical Engineering Journal, 6:201-205 (2000).
Terashima, M. et al., “Production of functional human α1-antitrypsin by plant cell culture,”Appl. Microbiol. Biotechnol.,52:516-523 (1999).
van Lier et al., “Long-term semi-continuous production of recombinant baculovirus protein in a repeated (fed-) batch two-stage reactor system”, Enzyme and Microbial Technology 18:460-466 (1996).
Glick et al., “Molecular Biotechnology: Principles and Applications of Recombinant DNA”, ASM Press, Washington, D.C., p. 312, lines 1-8, (1994).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Process for scaled-up production of recombinant proteins... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for scaled-up production of recombinant proteins..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for scaled-up production of recombinant proteins... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3526382

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.