Process for resolving the enantiomers of a benzopyran derivative

Details Process for resolving the enantiomers of a benzopyran derivative Process for resolving the enantiomers of a benzopyran derivative

1990-02-14

1990-08-28

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D40100

Patent

active

049526960

ABSTRACT:
The invention relates to a process for resolving the enantiomers of trans-3-hydroxy-3,4-dihydro-2,2-dimethyl-4-(2-oxo-1,2-dihydropyridin-1-yl) -2H -1-benzopyran-6-carbonitrile (I), characterized in that racemic I, together with a small amount of (-)-I [or (+)-I], is dissolved in an inert solvent or solvent mixture, the solution is seeded with (-)-I [or (+)-I], the (-)-I [or (+)-I] which has precipitated is isolated, further racemis I is dissolved in the filtrate, the mixture is seeded with (+)-I [or (-)-I], the (+)-I [or (-)-I] which has precipitated is isolated, and if desired this crystallization cycle is repeated once or several times.

REFERENCES:
patent: 4788305 (1988-11-01), Tessier et al.

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