Process for resolving D, L-leucine

Details Process for resolving D, L-leucine Process for resolving D, L-leucine

1979-09-17

1981-03-31

Castel, Benoit

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435116, 435280, C12Q 138, C07B 1902

Patent

active

042594413

ABSTRACT:
Production of optically pure D-leucine and L-leucine ester by treating a racemic mixture of N-acyl-D,L-leucine ester with a proteolytic enzyme and separating the resulting N-acyl-L-leucine and N-acyl-D-leucine ester from the solution with subsequent removal of the N-acyl and ester groups to provide L-leucine and D-leucine, respectively.

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patent: 3963573 (1976-06-01), Stauffer
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Greenstein et al., "Chemistry of the Amino Acids", vol. 3, J. Wiley & Sons, N.Y., pp. 2080-2085 (1961).
Guntelberg et al., "Purification of the Proteolytic Enzyme from Bacillus Subtilis", C. R. Trav. Lab., Carlsberg, Ser. Chim. 29 (1954).
Subramanian et al., "The Major Alkaline Proteinase of Aspergillus Oryzae, Aspergillopeptidene", Biochem. vol. 3, No. 12., pp. 1861-1874 (1964).
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