Process for resolving alanine, 3-fluoro and 2-deutero-3-fluoro-D

Details Process for resolving alanine, 3-fluoro and 2-deutero-3-fluoro-D Process for resolving alanine, 3-fluoro and 2-deutero-3-fluoro-D

1976-03-05

1977-09-13

Thomas, Jr., James O.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424319, C07C10110, A61K 31195

Patent

active

040482243

ABSTRACT:
DL-Alanine, 3-fluoro-DL-alanine and 2-deutero-3-fluoro-DL-alanine, are resolved by reaction with a resolving base and a .beta.-dicarbonyl compound. The resulting azomethine diastereomeric salts which are easily separated, the masking group is readily removed under mildly acidic conditions.

REFERENCES:
patent: 3028395 (1962-04-01), Gillingham
patent: 3381031 (1968-04-01), Dwyer et al.
Dane et al., Agnew. Chem. Internat., Edit. 1,658 (1962).
Poroshin et al., Chem. Abst., vol. 80, 48400; (1974).
Asai et al., Chem. Abst., vol. 80, 133825w (1974).
Rogozhin et al., Chem. Abst., vol. 82, 98436n (1975).

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