Process for resolution of racemic DL-.alpha.-aminocarboxylic aci

Details Process for resolution of racemic DL-.alpha.-aminocarboxylic aci Process for resolution of racemic DL-.alpha.-aminocarboxylic aci

1978-11-01

1981-08-25

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

562401, C07C10104, C07C10106, C07C10108, C07B 1900

Patent

active

042858844

ABSTRACT:
In a process for resolving racemic DL-.alpha.-aminocarboxylic acids the said acids are reacted in an inert solvent with an aromatic o-hydroxy aldehyde to obtain an azomethine derivative which is reacted in the same stage with an optically active amine base to give a salt. The diastereomeric salt obtained is separated and the respective optically active .alpha.-aminocarboxylic acid is obtained therefrom by an acid treatment. By this process aliphatic and aromatic .alpha.-amino-carboxylic acids can be resolved, especially p-hydroxyphenyl glycine.

REFERENCES:
patent: 3976680 (1976-08-01), Clark et al.
patent: 4048224 (1977-09-01), Chemerda et al.
Bergmann et al., Zeitschrift fuer Physiol., Chemie, vol. 152, pp. 282-299, (1926).
Sheehan et al., Journal of Organic Chemistry, vol. 84, pp. 2417-2420, (1962).
Halpern et al., Chemistry and Industry, pp. 1399-1400, Aug. 17, 1963.
Hiskey et al., Journal of Organic Chemistry, vol. 31, pp. 3582-3587 (1966).
Kaneko et al., Synthetic Production and Utilization of Amino Acids, pp. 26 and 28, (1974).
Williams, Chemical Abstracts, vol. 80, article 105971t, (1974).
Bergmann et al., Chem. Ber., 58, 1034, (1925).
McIntire, J. Amer. Chem. Soc., 69, 1377, (1947).
Turner, Quart. Rev., 1, p. 299 et seq. (1947).
Weiland et al. Ann. Chem. 576, 104, (1952).
Biochem. J. 121, p. 425, (1971).
Wilen, "Tables of Resolving Agents and Optical Resolution" Notre Danem Ubduabam (1972).
Chem. Abs. vol. 81, 105971t (1974).

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