Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus acids or salts thereof
Patent
1994-06-06
1995-09-12
Dees, Jose G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Phosphorus acids or salts thereof
210724, 210906, 4233211, 562 8, 562124, C07F 938
Patent
active
054498198
ABSTRACT:
Disclosed is a process for removing by-product phosphorus-containing (PO.sub.x) materials, alendronate and alendronate byproducts from crude mother liquors in an omega amino-1-hydroxy-C.sub.2 -C.sub.6 alkylidene-1,1-bisphosphonic acid synthesis process, e.g. alendronate sodium. Calcium chloride is added first to the crude mother liquors, then calcium oxide to precipitate the PO.sub.x materials, then neutralized to about pH 7 to complete precipitation. Substantially all of the alendronate sodium active ingredient is removed from the precipitate. Following filtration, the PO.sub.x filtercake can then be disposed of by incineration, landfilling or reclamation of usable phosphorus as fertilizer. The remaining filtrate can then be further treated in an environmentally acceptable manner by wastewater treatment or recycling to the process.
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Forman Andrew L.
Magliette, Jr. Ralph J.
McKinney Donald
Venkataramani Edamanal S.
Dees Jos,e G.
DiPrima Joseph F.
Frazier Barbara S.
Merck & Co. , Inc.
North Robert J.
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